The loss of endothelium-dependent vascular relaxation in hypertension.
نویسندگان
چکیده
منابع مشابه
The loss of endothelium-dependent vascular relaxation in hypertension.
We investigated endothelium-dependent relaxation in rat aortae, using three models of experimental hypertension: deoxycorticosterone and salt; one-kidney, one clip renovascular hypertension; and coarctation. Isolated aortae were contracted with phenylephrine, and relaxation was subsequently induced with acetylcholine or calcium ionophore A23187. Blood vessels denuded of endothelium did not rela...
متن کاملAbnormal endothelium-dependent vascular relaxation in patients with essential hypertension.
BACKGROUND Endothelium regulates vascular tone by influencing the contractile activity of vascular smooth muscle. This regulatory effect of the endothelium on blood vessels has been shown to be impaired in atherosclerotic arteries in humans and animals and in animal models of hypertension. METHODS To determine whether patients with essential hypertension have an endothelium-dependent abnormal...
متن کاملAbnormal Endothelium-Dependent Vascular Relaxation of Patients With Essential Hypertension
Background. Patients with essential hypertension have abnormal endothelium-dependent vasodilation. Because the endothelium exerts its action on the vascular smooth muscle through the release of several substances, it is important to identify which of these factors is involved in the abnormal response of hypertensive arteries. Methods and Results. To investigate the role of endothelium-derived n...
متن کاملUltrastructural studies of pial vascular endothelium following damage resulting in loss of endothelium-dependent relaxation.
The changes in pial arterioles of 7 cats were examined by electron microscopy after injury that eliminates endothelium-dependent relaxation to acetylcholine or bradykinin. The injury was produced by exposing the vessels to mercury light in situ in the presence of intravascular sodium fluorescein dye. Previous studies showed that, at the time of initial injury and loss of endothelium-dependent r...
متن کاملAbnormalities of Endothelium-dependent Vascular Relaxation in Patients with Essential Hypertension
Managing Editor William E. James, PhD Postgraduate Institute for Medicine Stevo Julius, MD, ScD The University of Michigan Medical Center Robert A. Kloner, MD, PhD The Heart Institute University of Southern California Laurence R. Krakoff, MD Mount Sinai School of Medicine Englewood Hospital & Medical Center Franz H. Messerli, MD, FACC, FACP Ochsner Clinic Michael A. Weber, MD The Brookdale Hosp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 1986
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.8.6_pt_2.ii61